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相关概念视频

Steady State Concentration01:05

Steady State Concentration

4.9K
A steady state refers to the level of a drug in the body once it has reached an equilibrium between administration and elimination. It represents the point at which the drug administration rate equals the drug elimination rate, resulting in a relatively constant concentration in the body over time. The dynamic equilibrium is crucial to ensure the drug's effectiveness with minimal risk of toxicity.
Most drugs are administered in repeated doses at fixed intervals or through continuous...
4.9K
Ion Exchange01:17

Ion Exchange

657
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
657
Capillary Electrophoresis: Applications01:30

Capillary Electrophoresis: Applications

527
Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
527
The Equilibrium Constant03:10

The Equilibrium Constant

49.2K
Consider the oxidation of sulfur dioxide:
49.2K
Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

4.8K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.8K
Solution Equilibrium and Saturation01:59

Solution Equilibrium and Saturation

19.4K
Imagine adding a small amount of sugar to a glass of water, stirring until all the sugar has dissolved, and then adding a bit more. You can repeat this process until the sugar concentration of the solution reaches its natural limit, a limit determined primarily by the relative strengths of the solute-solute, solute-solvent, and solvent-solvent attractive forces. You can be certain that you have reached this limit because, no matter how long you stir the solution, undissolved sugar remains. The...
19.4K

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相关实验视频

Updated: Sep 9, 2025

Spin Saturation Transfer Difference NMR SSTD NMR: A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes
11:44

Spin Saturation Transfer Difference NMR SSTD NMR: A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes

Published on: November 12, 2016

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纯稳定状态 CEST

Johannes Hammacher1, Christoph Kolbitsch1, Patrick Schünke1

  • 1Physikalisch-Technische Bundesanstalt (PTB), Berlin and Braunschweig, Abbestrasse 12, Berlin, 10587, Berlin, Germany.

Magnetic resonance imaging
|September 3, 2025
PubMed
概括
此摘要是机器生成的。

一个新的化学交换和转移 (CEST) 序列设计通过在纯CEST稳定状态下获取数据来实现高性能. 这种新的方法在各种实验环境中提高了灵敏度和图像质量.

关键词:
时间表时间间隔螺旋式稳定状态

更多相关视频

The Benthic Exchange of O2, N2 and Dissolved Nutrients Using Small Core Incubations
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The Benthic Exchange of O2, N2 and Dissolved Nutrients Using Small Core Incubations

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Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone
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Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

Published on: February 23, 2017

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相关实验视频

Last Updated: Sep 9, 2025

Spin Saturation Transfer Difference NMR SSTD NMR: A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes
11:44

Spin Saturation Transfer Difference NMR SSTD NMR: A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes

Published on: November 12, 2016

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The Benthic Exchange of O2, N2 and Dissolved Nutrients Using Small Core Incubations
10:11

The Benthic Exchange of O2, N2 and Dissolved Nutrients Using Small Core Incubations

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Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone
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Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

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科学领域:

  • 磁共振成像技术
  • 生物医学工程

背景情况:

  • 化学交换和转移 (CEST) 是一种功能性MRI技术.
  • 优化CEST序列对于提高灵敏度和诊断能力至关重要.
  • 现有的CEST序列在实现一致的数据采集和高信号噪声比方面面临挑战.

研究的目的:

  • 开发和验证一种新的稳定状态化学交换和转移 (CEST) 序列.
  • 利用纯粹的CEST稳定状态来提高灵敏度和CEST效应.
  • 与传统方法相比,提高图像质量和MTRasym分数.

主要方法:

  • 一个基于纵向磁化的物理模型设计的新型稳定状态CEST序列.
  • 序列设计经过了严格的测试,使用体数值模拟.
  • 通过体外和体内实验进行了验证.

主要成果:

  • 开发的Multi- 2D螺旋纯稳定状态CEST序列显示出更高的灵敏度和有效性.
  • 在纯CEST稳定状态下实现了一致的数据采集.
  • 在体外和体内观察到高MTRasym分数和更好的图像质量.

结论:

  • 在纯CEST稳定状态内获取数据是增强CESTMRI的一个有希望的策略.
  • 新的序列设计显示出改善诊断应用的巨大潜力.
  • 进一步的体外和体内研究是有必要的,以充分探索这种技术的功能.