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Updated: Sep 9, 2025

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
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剖析Cdc37辅助器代码:辅助器介导应激适应中的功能作用

Megan M Mitchem1, Ashley Choi1, Duhita A Mirikar1

  • 1Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223.

The Journal of biological chemistry
|September 3, 2025
PubMed
概括

化Cdc37,一个蛋白激酶辅助子,对于细胞应激耐受性至关重要. 这项研究揭示了34个新的酸化位点,这些位点以环境依赖的方式调节Cdc37的功能,从而影响蛋白质稳定.

关键词:
细胞分裂周期37Hsp90 (热冲击90) 在陪伴者翻译后修改 (PTM)蛋白质稳定性应激反应酵母

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