模拟目标试验的观察性研究的透明报告:TARGET声明
Aidan G Cashin1,2, Harrison J Hansford1,2, Miguel A Hernán3,4,5
1Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.
BMJ (Clinical research ed.)
|September 3, 2025
概括
新的TARGET准则改善了模拟目标试验的观察性研究的报告. 这提高了非随机研究的因果效应估计的透明度和解释性.
科学领域:
- 流行病学
- 生物统计学
- 卫生研究方法
背景情况:
- 当随机试验不可行时,观察性研究对于因果推断至关重要.
- 现有的报告指南对于模拟目标试验的研究是不够的.
- 缺乏标准化的报告阻碍了研究结果的解释和应用.
研究的目的:
- 为模拟目标试验的观察性研究制定基于共识的报告指南.
- 提高健康研究中因果关系估计的透明度和质量.
主要方法:
- 使用EQUATOR框架制定了模拟目标试验的观察性研究透明报告 (TARGET) 准则.
- 方法包括系统审查,专家调查,共识会议和利益相关者试点.
- 准则的制定涉及18名专家和108名利益相关者的反.
主要成果:
- 创建了一个21项的TARGET检查清单,分为六个部分.
- 关键建议包括将研究确定为目标试验模拟,并指定目标试验方案.
- 指南涵盖报告因果估计,假设,数据分析和敏感性分析.
结论:
- 该指南旨在提高模拟目标试验的观察性研究的报告透明度和同行评审.
- 加入TARGET将有助于研究人员,临床医生和读者解释和应用研究结果.
- 通过加强报告,可以从观察数据中得出更可靠的因果推断.
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