患有COVID-19肺炎住院患者的肺气泡过渡
Hooman Poor1, Adeel Abassi2, Daniel Howell3
1Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA hooman.poor@mountsinai.org.
BMJ open respiratory research
|September 3, 2025
概括
肺气泡传输 (TPBT) 在COVID-19肺炎患者中很常见,并且随着时间的推移而增加. 与心率上升相结合的TPBT与住院死亡风险的增加有关.
科学领域:
- 心脏病学
- 肺病学
- 神经学
背景情况:
- 在COVID-19肺炎中传播肺气泡 (TPBT) 的流行需要进一步调查.
- 之前的研究表明使用跨多普勒 (TCD) 的TPBT发生率很高.
研究的目的:
- 确认并进一步调查住院的COVID-19肺炎患者中TPBT的流行情况.
- 评估TPBT,心率和住院死亡率之间的关联.
主要方法:
- 招募了91名需要呼吸支持的COVID-19肺炎患者.
- 在招募时和大约7天和14天进行了跨多普勒 (TCD) 研究.
- 参与者接受了各种形式的呼吸辅助,包括鼻管,高流量鼻管,非侵入性通风,机械通风和ECMO.
主要成果:
- 36%的参与者在最初的TCD上显示了TPBT.
- 在第二次评估中,TPBT的流行率增加到55%,在第三次评估中增加到85%.
- 与心率升高相结合的TPBT与住院死亡的增加有关 (p=0.02).
结论:
- 住院的COVID-19肺炎患者中TPBT的患病率高于之前报告的.
- 在幸存的住院患者中,TPBT的患病率随着时间的推移而增加.
- 在TPBT患者中,心率升高是死亡率的重要预测因素.
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