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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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在异性血源干细胞移植后的多瘤病毒脑炎的临床特征,危险因素和结果

Xu-Ying Pei1, Xian-Ying Yin1, Hai-Lu Sun1

  • 1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.

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概括

在干细胞移植后的多瘤病毒 (PyV) 脑炎导致不良结果. 这种感染,包括BK病毒 (BKV) 和JC病毒 (JCV) 脑炎,显著增加死亡率并降低生存率.

关键词:
BKV 在联合 CV不同基因的造血干细胞移植大脑炎多种瘤病毒

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科学领域:

  • 传染性疾病
  • 血液学
  • 神经科学

背景情况:

  • 多种瘤病毒 (PyV) 脑炎是一种严重的机会性感染.
  • 它经常与渐进的多焦点白内障病 (PML) 相关.
  • PyV脑炎是一种已知的异构造血干细胞移植 (allo-HSCT) 后的并发症.

研究的目的:

  • 研究PyV脑炎的临床结果.
  • 为了比较不同类型的PyV (BKV,JCV) 和对照组的结果.
  • 评估PML对该患者群体的死亡率和存活率的影响.

主要方法:

  • 这是一项回顾性队列研究,涉及54名被诊断患有PyV脑炎的患者.
  • 用1:4的比率进行病例对照设计.
  • 对6个月,1年和3年的非复发死亡率 (NRM) 和整体存活率 (OS) 的分析.

主要成果:

  • 诊断的中位时间为HSCT后77天.
  • 常见的症状包括发作,头痛和运动功能障碍.
  • 与对照组相比,PyV脑炎患者的3年NRM显著增加 (32. 0%对比13. 5%) 和3年OS降低 (60. 6%对比76. 6%).
  • BK病毒 (BKV) 和JC病毒 (JCV) 脑炎表现出类似的不良结果 (3 年NRM: 31. 5% 与 25. 0% 相比; 3 年OS: 61. 5% 与 62. 5% 相比).
  • 在51. 8%的病例中发生了渐进的多焦点白内障,对NRM或OS没有显著影响.

结论:

  • 合后的PyV脑炎与显著较差的临床结果有关.
  • BK病毒和JC病毒脑炎具有相似且不利的预后.
  • 在该队列中,PML的存在没有显著改变死亡率或存活率.