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血清戈尔吉蛋白-73 (GP-73) 在自身免疫性肝炎的儿童中

Marwa Sabry Rizk¹, Ola Galal Ali Behairy², Amera Mohamed Abdel Salam Dawood³

¹Pediatric Hepatology, Gastroenterology and Nutrition Department, National Liver Institute, Menoufia University, Menoufia, Egypt.

European journal of pediatrics

|September 3, 2025

概括

在患有自身免疫性肝炎的儿童中,血清戈尔吉蛋白-73 (GP-73) 升高,与肝纤维化严重程度相关. 这种生物标志物对儿童自身免疫性肝病的非侵入性评估和治疗具有前景.

科学领域:

儿童肝病学
免疫学
生物标志物发现

背景情况:

在儿童自身免疫性肝炎中评估肝纤维化的非侵入性生物标志物有限.
肝脏活检是目前的黄金标准,
血清戈尔吉蛋白-73 (GP-73) 已成为一种潜在的非侵入性标记物.

研究的目的:

在患有自身免疫性肝病的儿童中,评估血清GP-73水平与肝纤维化程度之间的相关性.
评估GP-73的诊断准确性,以识别儿科患者的自身免疫性肝炎 (AIH) 和严重纤维化.

主要方法:

一项涉及100名儿童的病例对照研究:50名患有AIH和50名健康对照.
使用酶相关免疫吸收试验 (ELISA) 测量了GP-73的血清水平.
分析了与组织学活性指数和纤维化阶段的相关性.

主要成果:

与对照组相比,患有AIH的儿童的血清GP-73水平显著更高 (中位数为110. 7 ng/ L与21. 3 ng/ L,p < 0. 001).
与组织学活性 (r=0. 879, p < 0. 001) 和纤维化阶段 (r=0. 647, p < 0. 001) 强烈相关.
截止值>49 ng/L证明了AIH检测的100%灵敏度和特异性;>124.6 ng/L确定了100%灵敏度和91.7%特异性的严重纤维化.

结论:

在患有自身免疫性肝炎的儿童中,血清GP-73显著升高.
肝纤维化的组织学分级和阶段与GP-73水平有很强的相关性.
GP-73是一种可靠的非侵入性生物标志物,用于评估疾病严重程度和指导儿童自身免疫性肝病的治疗.

关键词:

自体免疫性肝炎孩子们肝脏纤维化血清高尔基蛋白-73

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