通过HPCell从空间组织学图像准确预测细胞类型丰富性
Yongkang Zhao1, Youyang Li2, Weijiang Yu3
1School of Big Data and Software Engineering, Chongqing University, Chongqing, 400044, China.
Interdisciplinary sciences, computational life sciences
|September 3, 2025
概括
通过深度学习,HPCell从组织学图像中推断出细胞类型的丰富性,克服了空间转录学 (ST) 的成本障碍. 这种方法准确地绘制了组织细胞性,推进了ST应用.
科学领域:
- 计算生物学
- 基因组学
- 病理学
背景情况:
- 空间转录学 (ST) 提供了对组织架构和细胞相互作用的无与伦比的见解.
- 高的测序成本限制了ST的广泛采用.
- 现有的方法通常可以预测转录形状,但很少从组织学图像直接估计细胞类型的丰度.
研究的目的:
- 开发一个具有成本效益的深度学习框架,HPCell,直接从H&E染色组织学图像中推断细胞类型的丰度.
- 解决空间转录学中高测序成本的局限性.
主要方法:
- HPCell使用了深度学习框架,包括病理基础,超图和变压器模块.
- 整片图像 (WSIs) 被修补并处理为形态特征.
- 一个超图模型的空间关系, 和一个变压器捕捉长距离的依赖.
主要成果:
- 通过组织学图像,HPCell准确估计细胞类型的丰度.
- 与最先进的方法相比,该框架在多个ST数据集中显示出更高的性能.
- HPCell提供了一种可扩展且具有成本效益的组织分析解决方案.
结论:
- HPCell为ST细胞类型丰度估计提供了昂贵的测序的可行替代方案.
- 这种方法有助于更深入地了解组织结构和细胞相互作用.
- HPCell有可能显著扩大空间转录学的可访问性和应用.
相关概念视频
02:13Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
02:13Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...