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杜申肌肉衰竭中的神经障碍:综合性审查

Xiao-Fang Zhang¹, Wenguang Hu¹, Jie Hu²

¹Department of Pediatric Neurology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Acta neurologica Belgica

|September 3, 2025

概括

杜申肌肉发育不良 (DMD) 导致神经问题,如由于大脑发育不良的认知障碍. 治疗的目的是恢复消毒素或管理下游效应以获得更好的临床策略.

科学领域:

神经学
遗传学
分子生物学

背景情况:

杜申肌肉衰竭 (DMD) 是最常见的肌肉衰竭.
神经系统并发症,包括认知障碍,在DMD中很普遍.
这些神经问题的主要原因是大脑营养不良.

研究的目的:

审查最近关于DMD神经表现的文献.
为临床管理提供理论框架.
在DMD中综合发现大脑变化和分子异常.

主要方法:

神经成像研究和分子研究的文献综合.
对结构,血液动力学和代谢大脑变化的分析.
对治疗策略的审查,以向色素表达和下游效应.

主要成果:

神经成像显示大脑结构的改变, 血液动力学障碍, 和代谢失调在DMD.
神经功能障碍源于大脑营养不良,导致激发抑制平衡的改变,BBB干扰,失调和神经炎症.
目前的治疗重点是增强大脑中切断的质蛋白或解决下游的后果.

结论:

神经性并发症是杜申肌肉衰竭的一个重要方面.
对于开发有效的治疗方法至关重要.
临床治疗需要一个综合的方法,结合复原和下游效应的管理.

关键词:

杜申肌肉衰竭双氨酸的异形神经系统损伤突触可塑性

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