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研究血清NRF2作为查生物标志物和糖尿病足的潜在治疗:一项前性观察研究

Wentao Yang¹, Hui Cao¹, Song Lin²

¹Department of Plastic Surgery, Fancheng District, Xiangyang No.1 People's Hospital, Hubei University of Medicine, No.15, Jiefang Road, Xiangyang, 441000, Hubei, China.

European journal of medical research

|September 3, 2025

概括

较低的血清核因子红色素2相关因子 (NRF2) 水平表明严重的糖尿病足 (DFU). NRF2作为一种潜在的生物标志物,用于识别严重的DFU病例和相关的风险因素.

科学领域:

生物化学
免疫学
临床医学

背景情况:

糖尿病足 (DFU) 是糖尿病的一个严重并发症,通常与炎症和氧化应激有关.
核红素因子2 (NRF2) 是抗氧化和抗炎反应的关键调节剂.
了解DFU严重性的生物标志物对于及时干预和改善患者结果至关重要.

研究的目的:

研究血清NRF2水平与糖尿病足 (DFU) 的严重程度之间的关联.
确定可能导致严重的DFU的风险因素.
评估NRF2作为严重的DFU生物标志物的诊断价值.

主要方法:

根据瓦格纳标准分类的195名DFU患者的前性观察研究.
测量血清NRF2,C反应蛋白 (CRP),干白素-6 (IL-6),干白素-17 (IL-17) 和瘤死因α (TNF-α).
包括后勤回归和ROC曲线分析在内的统计分析,以评估NRF2的诊断效用和与DFU严重性的关联.

主要成果:

严重的DFU患者与轻度的DFU患者相比,血清NRF2水平显著降低.
在严重的DFU组中观察到IL-6,IL-17和CRP的升高水平.
NRF2显示出严重的DFU可靠的查能力,NRF2的降低被确定为独立的风险因素.

结论:

血清NRF2水平可以作为识别严重DFU的有价值的查生物标志物.
将NRF2与其他生物标志物相结合,可以提高患者分层和DFU的临床管理.
需要进一步的研究来证实NRF2在DFU治疗中的治疗潜力.

关键词:

生物标志物糖尿病足炎症标志物其他类型氧化应激

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