系统性免疫炎症指数和中性粒细胞与淋巴细胞的比例:与过度活跃的膀的U形关联
Qinglong Yang1, Haolin Chen2, Hanyuan Lin1,3
1Department of Urology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Lower urinary tract symptoms
|September 3, 2025
概括
系统性免疫炎症指数 (SII) 和中性细胞与淋巴细胞的比率 (NLR) 可能表明膀过活的风险. 观察到U型关联,较高的SII和NLR与OAB患病率的增加有关.
科学领域:
- 尿道病学
- 免疫学
- 公共卫生
背景情况:
- 过度活跃的膀 (OAB) 是影响生活质量的常见疾病.
- 在各种慢性疾病中越来越多地发现了炎症和免疫反应.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 和中性粒细胞与淋巴细胞比率 (NLR) 与膀过活的流行情况之间的联系.
主要方法:
- 使用NHANES数据 (2005 - 2018) 对22343名美国成年人 (≥20岁) 的横截面研究.
- 使用加权多变量逻辑回归和受限立方线 (RCS) 分析.
- 为了验证结果,进行了子组和敏感性分析.
主要成果:
- RCS分析显示SII和NLR与OAB之间存在U形关系.
- 增加的SII (> 6. 13) 和NLR (> 0. 65) 与OAB患病率呈正相关性 (OR分别为1. 32和1. 40).
- 较低的SII (≤6. 13) 与OAB (OR 0. 83) 有负相关性.
结论:
- SII和NLR显示为过活性膀风险的预测生物标志物.
- 这些炎症标志物可能有助于识别患有OAB风险较高的人.
相关概念视频
Urinary Tract Infection II: Pathophysiology
43
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
43
Urinary Bladder
1.4K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
1.4K
Nursing Assessment of the Genitourinary System I: Health History
75
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
75
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
35
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
35
Nursing Assessment of the Genitourinary System II: Inspection and Palpation
221
The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
221
Urinary Tract Infection I: Introduction
47
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
47


