使用转录组技术解读正常和疾病的大动脉生物学的最新进展

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Updated: Sep 9, 2025

Isolation of Human Primary Valve Cells for In vitro Disease Modeling
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Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

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Monica Madalina Tucureanu1, Ileana Manduteanu1

  • 1Institute of Cellular Biology and Pathology "Nicolae Simionescu", Bucharest, Romania.

Journal of cellular and molecular medicine
|September 4, 2025
PubMed
概括

动脉疾病 (CAVD) 缺乏治疗方法. 本综述使用转录学来探索大动脉 (AV) 细胞生物学,确定CAVD的潜在治疗点.

关键词:
大动脉的生理学甲状腺膜疾病多种类型治疗目标转录组学

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Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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