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研究领域生物医学和临床科学心血管医学和血液学血液学
血小板输血对受控内毒素和血液瘤患者的血蛋白质的影响

血小板输血对受控内毒素和血液瘤患者的血蛋白质的影响

Eva R Smit ¹, Isabella Viegen ², Pieter F van der Meer ^3,4, Stefan F van Wonderen ^2,5, Floor L F van Baarle ^2,5, Paula F Ypma ³, Jean-Louis H Kerkhoffs ^3,6, Jan Voorberg ^1,7, Alexander P J Vlaar ^2,5, Anna L Peters ², Maartje van den Biggelaar ¹, Diana Muñoz Sandoval ¹

Eva R Smit ¹, Isabella Viegen ², Pieter F van der Meer ^3,4

¹Department of Molecular Hematology, Sanquin Research, Amsterdam, the Netherlands.
²Department of Intensive Care, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
³Department of Hematology, Haga Teaching Hospital, The Hague, the Netherlands.
⁴Department of Product and Process Development, Sanquin Blood Bank, Amsterdam, the Netherlands.
⁵Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
⁶Unit Transfusion Medicine, Sanquin Blood Bank, Amsterdam, The Netherlands.
⁷Department of Experimental Vascular Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.

⁰Department of Molecular Hematology, Sanquin Research, Amsterdam, the Netherlands.

Transfusion +

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2025年九月4日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

血小板输血并没有使健康人或重症患者的炎症恶化. 虽然在患者中观察到一些蛋白质水平的变化,但总体而言,输血似乎没有诱导炎症或其他失调的过程.

科学领域

生物化学
免疫学
血液学

背景情况

在接受血小板输血的患者中,炎症很常见,可能导致并发症.
人们怀疑血小板输血会使炎症状况恶化.

研究的目的

使用蛋白质组学研究血小板输血在炎症条件下对血蛋白质的影响.
确定血小板输血是否会加剧健康志愿者和血液瘤患者的炎症.

主要方法

在接受输血的健康志愿者 (n=252) 及血液瘤患者 (n=54) 的样本上进行了血蛋白质分析.
采集了输血前和输血后的样本以分析蛋白质水平的变化.

主要成果

在健康志愿者中,内毒素引起了明显的炎症蛋白反应 (S100A9,MMP9,SAA,CRP).
在健康人群中,自身血小板输血没有改变血蛋白或加剧内毒素引起的炎症.
血小板输血导致血小板基本蛋白 (PPBP) 水平增加,没有其他显著的炎症变化.

结论

在健康志愿者中,血小板输血没有引起显著的血蛋白质量变化.
在血液瘤患者中,在输血后发现了PPBP的特定增加.
整体而言,血小板输血没有引起炎症或其他失调的过程.

关键词:

控制的内毒性血液瘤学血的血小板蛋白质组学进行输血

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相关概念视频

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

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