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Updated: Sep 9, 2025

Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
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具有免疫调节性质的多多巴胺合NT3导电支架加速外围神经再生

Xiaokun Chen1, Jihai Xu2, Ziyuan Yang3,4,5

  • 1Department of Orthopedic Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Neural regeneration research
|September 4, 2025
PubMed
概括

这项研究开发了一种新的神经管道,可以清除反应性氧物种,调节免疫反应,并提供电气和地形线索来增强外围神经的再生. 在老鼠模型中,多功能导管促进了神经修复和功能恢复.

关键词:
碳纳米管电旋神经导管免疫调节神经增生蛋白-3周围神经的再生

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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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