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高腰与身高的比率增加了1型糖尿病成人心血管结果的风险:全国性队列研究

Kyeong-Jin Kim1, Seohyun Kim1, Rosa Oh1

  • 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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概括
此摘要是机器生成的。

中部肥胖,以高腰与身高的比率 (WHtR) 表示,显著增加1型糖尿病 (T1DM) 患者心血管疾病 (CVD) 的风险. 通过WHtR的早期检测可以帮助管理这一群体的心脏病风险.

关键词:
心血管疾病糖尿病类型 1肥胖,腹部疾病

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科学领域:

  • 心脏病学
  • 内分泌学
  • 公共卫生

背景情况:

  • 中心肥胖是心血管疾病 (CVD) 和死亡的已知危险因素.
  • 腰与身高的比例 (WHtR) 是中心肥胖的实用和可访问的标志物.
  • 在1型糖尿病 (T1DM) 患者中,WHtR与综合性心血管结局之间的关联需要进一步研究.

研究的目的:

  • 调查1型糖尿病 (T1DM) 的成年人腰与身高比率 (WHtR) 和心血管 (CV) 结果之间的关联.
  • 确定WHtR是否可以作为T1DM群体中CV事件的预测标志物.

主要方法:

  • 在全国范围内分析了16928名韩国成年T1DM患者 (2006-2020年).
  • 参与者分为三个WHtR组:<0. 5,0. 5至<0. 6和≥0. 6.
  • 主要结局包括复合心血管事件 (心力衰竭,心肌梗塞,缺血性中风,心血管疾病相关死亡),并对单个组件进行二次分析.

主要成果:

  • 在较高的WHtR和复合心血管事件的风险增加之间发现了显著的关联.
  • 与WHtR<0. 5相比,WHtR≥0. 6显示风险增加了1. 62倍 (aHR为1. 62;95% CI为1. 38-1. 90;P<0. 001).
  • 增加的WHtR与心力衰竭,心肌梗塞,缺血性中风和与心血管疾病相关的死亡风险增加有关.

结论:

  • 高腰与身高的比率是1型糖尿病成年人心血管事件的重要独立预测因子.
  • WHtR可以作为一种有价值的查工具来识别心血管并发症高风险的T1DM患者.