不复杂的双胞胎:神经发育的见解和影响
D Casati1, M M Lanna1, D Consonni2
1Fetal Therapy Unit "U. Nicolini", Buzzi Children's Hospital, University of Milan, Milan, Italy.
概括
轻度神经发育障碍在没有并发症的双胞胎中很常见,自闭症谱系障碍 (ASD) 的风险增加. 早期检测和标准化后续对最佳结果至关重要.
科学领域:
- 周围生理学
- 儿童发育医学
- 双胞胎研究
背景情况:
- 由于共享胎盘,双胞胎表现出独特的生理适应性.
- 没有并发症的MCDA双胞胎的长期神经发育结果需要进一步研究.
- 早期发现神经发育风险对于及时干预至关重要.
研究的目的:
- 评估三岁以下不复杂的MCDA双胞胎的神经发育结果.
- 确定与神经发育障碍 (NDI) 相关的风险因素.
- 为未来的研究和后续协议提出建议.
主要方法:
- 在怀孕34周之间出生的无并发性MCDA双胞胎 (n=138) 的观察队列研究.
- 使用贝利尺度进行神经发育评估和1,2,3岁的神经评估.
- 多变量后勤回归模型分析NDI与围产期/环境因素之间的关联.
主要成果:
- 平均贝利分数与单体相比较;然而,29. 0% 的患者有轻度NDI,5. 8% 的患者有重度NDI.
- 在11. 6%的婴儿中诊断出行为障碍,包括自闭症谱系障碍 (ASD).
- 呼吸困难综合征预测轻度NDI,而女性性别,更高的孕产妇年龄和更高的社会文化地位是保护性的.
结论:
- 在没有并发症的MCDA双胞胎中,轻微的神经发育障碍和更高的ASD发病率是常见的.
- 早期发现NDI对于缓解长期影响至关重要.
- 建议对MCDA双胞胎进行标准化的神经发育后续检查.
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