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[Monascus sanguineus的代谢物和抗炎作用]

Ji-Yuan Fan¹, Bing-Yu Liu², Hui-Ming Hua³

¹School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University Shenyang 110016, China Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

|September 4, 2025

概括

研究人员使用Monascus sanguineus从发酵大米中分离出38种化合物, 发现了四种新的天然产品. 化合物6通过抑制巨细胞模型中的氧化产生抗炎作用.

科学领域:

自然产品化学
药理学
微生物学

背景情况:

红是一种已知产生生物活性代谢物的真菌.
米的发酵可以产生多种化学化合物.
炎症是一种复杂的生物反应,

研究的目的:

用Monascus sanguineus发酵的水中分离和识别化合物.
评估这些隔离化合物的抗炎作用.

主要方法:

使用包括凝,ODS,Sephadex LH-20和HPLC在内的色谱技术进行隔离和净化.
使用光谱方法 (UV,IR,NMR,MS) 进行结构阐明,并计算出ECD.
使用脂聚糖 (LPS) 诱导的RAW264. 7巨细胞模型评估了抗炎活性.

主要成果:

共有38种化合物被分离和鉴定出来.
发现了四种新的天然产物,
在LPS刺激的巨细胞中,化合物6显著抑制了氧化的产生 (53. 08%).

结论:

用Monascus sanguineus发酵大米是一种可行的新型天然产品来源.
化合物6具有有前途的抗炎性质.
需要对化合物6的作用机制进行进一步的研究.

关键词:

红树 (Monascus sanguineus) 其他多基类二次代谢物结构识别

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