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相关概念视频

Path Between Thermodynamics States01:21

Path Between Thermodynamics States

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Consider the two thermodynamic processes involving an ideal gas that are represented by paths AC and ABC in Figure 1:
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Work and Energy for Variable Forces01:10

Work and Energy for Variable Forces

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When an object is acted upon by a variable force, the amount of work done and the change in energy of the object can be more complex to calculate compared to when a constant force is applied. Work is the product of force and displacement, while energy is the capacity of a system to do work. When a constant force is applied to an object, the work done can be calculated as the product of the force and the distance moved in the direction of the force. However, when a variable force is applied, the...
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Work-Energy Theorem for Motion Along a Curve01:09

Work-Energy Theorem for Motion Along a Curve

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The work-energy theorem can be generalized to the motion of a particle along any curved path. The simple argument here is that the curved path can be considered a sum of many infinitesimal paths, each of which is a straight path. The force on the particle can be considered constant along any such infinitesimal path so that the work-energy theorem can be applied along it. So, it is also valid for the sum of these paths. The net work done is the integral of the work done along the infinitesimal...
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Principle of Virtual Work: Problem Solving01:13

Principle of Virtual Work: Problem Solving

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The principle of virtual work is an essential concept in the field of mechanics and engineering. This is used to solve problems related to the equilibrium of a structure or system. It is based on the assumption that if a system is in equilibrium, the work done by all the forces during a virtual displacement is zero. This principle is applied by considering virtual displacements of the system and the corresponding work done by internal and external forces.
To apply the principle of virtual work,...
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Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

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Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
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Virtual Work for a System of Connected Rigid Bodies01:06

Virtual Work for a System of Connected Rigid Bodies

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Virtual work is a powerful method used to solve problems involving several connected rigid bodies. When the system is in equilibrium, virtual work is zero. This allows the calculation of the resulting forces when a system undergoes a virtual displacement. When attempting to analyze such a system, first, use a free-body diagram, where an independent coordinate represents the configuration of the links, and mark its deflected position resulting from the positive virtual displacement.
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相关实验视频

Updated: Sep 9, 2025

A Web Tool for Generating High Quality Machine-readable Biological Pathways
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确定最低工作途径:简单的例子

Ron Elber1,2

  • 1The Oden Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin TX, 78712.

Molecular physics
|September 4, 2025
PubMed
概括
此摘要是机器生成的。

我们开发了一种网络搜索方法, 这种方法有助于采样复杂的景观,并用于分子模拟.

关键词:
自由的能量分子动力学蒙特卡洛最低工作路径工作

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Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
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Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
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科学领域:

  • 计算化学
  • 统计力学
  • 物理化学

背景情况:

  • 最小工作路径 (MWP) 对于高效的免费能源计算至关重要.
  • 对于设计像候选蒙特卡洛移动这样的先进采样方法来说,MWP是必不可少的.
  • 在分子模拟中,有效采样复杂的能量场景是一个持续的挑战.

研究的目的:

  • 提出一种新的网格搜索方法来确定最小工作路径 (MWP).
  • 证明MWP网络搜索方法在多种系统中的适用性.
  • 在不同的潜在能源环境中分析MWP的行为和特征.

主要方法:

  • 实施网格搜索算法以系统地探索MWP的参数空间.
  • 该方法应用于二维模型景观以确定MWP.
  • 使用该方法研究Lennard-Jones球的突变过程中的MWP.

主要成果:

  • 在固定的短时间内成功识别二维景观示例中的最小工作路径 (MWP).
  • 在列纳德-斯突变示例中观察一条宽的最小工作路径,缺少单一的MWP.
  • 在具有不同复杂度的景观系统中验证网络搜索方法.

结论:

  • 网格搜索方法为计算最小工作路径 (MWP) 提供了一种可行的方法.
  • 一个明确的MWP是否存在取决于能源环境的具体特征.
  • 这种方法提供了系统穿越复杂的潜在能量表面的动态.