在食管切除术后星状块对预防心房的作用:双盲随机对照试验
Tieshuai Liu1, Jun Zhang1, Jingwen Liang1,2
1Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Drug design, development and therapy
|September 4, 2025
概括
在食道切除术后,手术前的星状关节阻塞 (SGB) 并没有减少术后心房动 (POAF). 然而,SGB改善了患者的康复,减少了疼痛,改善了胃肠功能,提高了睡眠质量.
科学领域:
- 心脏病学
- 麻醉学
- 胸部手术
背景情况:
- 手术后心房动 (POAF) 是食管切除术后的常见并发症,与患者的不良结果有关.
- 确定减轻POAF和增强恢复的策略对于改善手术结果至关重要.
研究的目的:
- 评估手术前星状关节阻断 (SGB) 降低食道切除术后POAF的发生率.
- 评估SGB对术后康复的各个方面的影响,包括疼痛,胃肠功能和睡眠质量.
主要方法:
- 一个单中心,随机,双盲,安慰剂对照试验,涉及100名接受食管切除的患者.
- 患者在手术前接受了超声导向右侧SGB与罗皮瓦卡因或安慰剂 (正常盐水).
- 主要结局:在72小时内发生POAF;次要结局:疼痛评分,心率变化,胃肠道恢复,睡眠质量和并发症.
主要成果:
- 在SGB和对照组中,POAF的发病率相似 (10%).
- 在手术后的第一天,SGB组的心脏收缩明显减少,疼痛得分降低,心率降低.
- 接受SGB治疗的患者经历了更快的胃肠道恢复 (更早的浮和第一次摄入) 并报告了更少的睡眠障碍.
结论:
- 手术前的SGB没有显著降低食道切除术后的POAF发病率.
- 施用SGB与术后恢复显著改善有关,包括疼痛控制,胃肠功能和睡眠质量.
- 这些发现表明SGB可能是优化食管切除术后患者康复的有价值补充,尽管它没有影响POAF率.
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