患有自闭症谱系障碍的儿童的视神经形态是否与非典型的视觉感官行为有关?
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在PubMed上查看摘要
概括
此摘要是机器生成的。与正常发育的同龄人相比,患有自闭症谱系障碍 (ASD) 的儿童表现出明显的脑部差异,包括更大的视觉 (OC) 高度,体 (CC) 和胆脉 (CP) 体积,以及更小的第三腹腔体积.
科学领域
- 神经成像
- 发展神经科学
- 自闭症谱系障碍研究
背景情况
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,表现不同.
- 了解自闭症的神经解剖学基础对于识别潜在的生物标志物和治疗点至关重要.
- 以前的研究表明,自闭症患者的大脑结构存在差异, 但具体的形态细节需要进一步调查.
研究的目的
- 使用MRI研究与典型发育 (TD) 儿童相比,ASD儿童的神经解剖学差异.
- 检查视神经直径,视 (OC) 形态测量,心室体积,大脑体积 (CC) 和胆体积 (CP).
- 将这些神经解剖学参数与ASD症状严重程度和感官敏感性相关联.
主要方法
- 有111名患有自闭症的儿童和143名TD儿童 (5至13岁) 接受了MRI.
- 通过社会沟通问卷 (SCQ) 和儿童自闭症评分表 (CARS) 评估自闭症的严重程度.
- 使用自闭症行为检查清单 (AuBC) 评估感官敏感性.
主要成果
- 自闭症组的OC高度,CP和CC体积显著增加;OC宽度较低,第三心室体积较大.
- 视神经体积,OC横截面积,侧面/第四腹腔体积或总脑体积没有显著差异.
- 左侧CP体积与自闭症诊断最强烈相关;OC高度与症状严重程度和感官评分相关.
结论
- 在自闭症中,大脑发育的变化可能涉及OC高度,CC和CP体积的增加,以及第三腹腔体积的减少.
- 这些神经解剖学发现有助于理解自闭症病因.
- 特定的形态测量,特别是左侧CP体积,显示出自闭症生物标志物的潜力.
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