在叶中表层和深层白质异常
Gerard R Hall1, Sarah J Gascoigne1, Jonathan J Horsley1
1CNNP Lab (www.cnnp-lab.com), School of Computing, Newcastle University, Newcastle upon Tyne NE4 5BX, United Kingdom.
Brain communications
|September 4, 2025
概括
表面白质 (WM) 在叶 (TLE) 中比深层白质 (WM) 减少更大. 这一发现甚至在MRI阴性患者中也是如此,这表明诊断中的侧向化可能存在.
科学领域:
- 神经成像和病研究
- 神经疾病中的白质完整性
背景情况:
- 非侵入性神经成像对于识别中脑部异常至关重要.
- 深白质 (WM) 的小分离异位变化 (FA) 是叶的已知标志物.
- 在中,表面肌肉异常的理解较少.
研究的目的:
- 在TLE中研究不同WM深度的扩散权重成像 (DWI) 异常.
- 在两个独立的TLE群体中比较表面与深层WM异常.
- 探索WM异常的临床实用性,包括MRI阴性病例.
主要方法:
- 分析两个TLE群体 (N=81和N=70) 的不同DWI获取方案 (多层和单层).
- 将FA地图注册为时间WM分析的标准模板.
- 在不同WM深度,ipsilateral和contralateralWM以及MRI阳性和MRI阴性组的FA测量结果的比较.
主要成果:
- 在TLE患者中,表面WM与深层WM相比显著减少FA (P< 0. 001).
- 这种表面WM异常在侧叶更明显 (P < 0. 001).
- 观察到的效应在TLE队列中一致,并且存在于MRI阴性患者中.
结论:
- 表面性脑膜炎在中比深层脑膜炎更容易受到影响.
- 表面层的WM FA异常可能有助于横向,即使在MRI阴性个体.
- 需要进一步研究表面肌痛在病发病和诊断中的作用.
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