在强心研究中,尿与发生的外周动脉疾病和截肢的相关性
Claire Howlett1, Filippo Ravalli1, Kishan Bhatt1
1Vagelos College of Physicians and Surgeons, Columbia University, 630 W 168th street, New York, NY 10032 USA.
概括
尿液中含量较高与周围动脉疾病 (PAD) 和截肢的风险增加有关. 这些关联在糖尿病患者中更强烈,突出显示
科学领域:
- 环境健康
- 心血管流行病学
- 代谢疾病研究
背景情况:
- 尿液中与心脏代谢疾病的关联已确立,但对周围动脉疾病 (PAD) 的证据仍然有限.
- 周围动脉疾病 (PAD) 和糖尿病相关的截肢是严重的公共卫生问题,特别是在美国印第安人中.
- 研究尿等新生物标志物对于了解PAD病变和风险分层至关重要.
研究的目的:
- 预期评估尿液中含量与PAD发生率之间的关联.
- 检查尿与糖尿病相关的截肢事件之间的关系.
- 探索糖尿病状况对这些关联的潜在影响.
主要方法:
- 使用来自强心研究 (SHS) 的数据,
- 包括2045名没有PAD和2180名没有截肢的参与者 (1989-1991).
- 通过对共变量进行调整,在10年的随访期内评估PAD事件 (按脚-手臂指数定义) 和截肢事件.
主要成果:
- 在调整社会人口统计和临床因素后,尿液中较高的含量与发生PAD (OR: 1. 29每次IQR增加) 和截肢 (OR: 2. 36每次IQR增加) 的几率增加有关.
- 这些关联在进一步调整糖尿病状况和空腹血糖后减弱.
- 在基线糖尿病患者中,尿与PAD之间的关联显著更强 (OR:1. 43).
结论:
- 这项研究确定了尿液中含量升高与患上PAD和截肢的风险增加之间的潜在关联.
- 这些发现表明尿液中的可能是PAD和截肢风险的潜在生物标志物,特别是在糖尿病患者中.
- 需要进一步研究以阐明代谢与周围血管健康之间的关系的生物学机制.
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