在COVID-19中评估维生素D状态,维生素D受体表达和先天免疫媒介
Ferdos Missilmani1, Dima Maarabouni1, Elie Salem-Sokhn1
1Molecular Testing Laboratory, Department of Medical Laboratory Sciences, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.
Frontiers in endocrinology
|September 4, 2025
概括
鼻子中的维生素D受体 (VDR) 和抗菌 (DEFA1-3) 基因表达与较低的COVID-19风险相关. 在黎巴嫩人中,维生素D水平与COVID-19风险没有直接关联.
科学领域:
- 免疫学和病毒学
- 营养生物化学
- 人类遗传学
背景情况:
- COVID-19 疫情凸显了影响感染易感性的宿主因素的必要性.
- 通过其受体 (VDR) 传递维生素D信号,以及与生俱来的免疫媒介,如抗菌 (DEFA1-3) 和化基因 (CCL20),对于抗病毒防御至关重要.
研究的目的:
- 调查血清维生素D状态与VDR,DEFA1-3和CCL20基因表达与COVID-19风险之间的联系.
- 在黎巴嫩人口群体中分析这些因素.
主要方法:
- 对264名黎巴嫩参与者进行了SARS-CoV-2检测的前性观察研究.
- 通过RT-qPCR对70个个体的血清25-维生素D[25(OH) D和鼻基因表达 (VDR,DEFA1-3,CCL20,GAPDH) 的量化.
- 统计分析包括多重后勤回归和皮尔森相关性.
主要成果:
- 鼻组织中的VDR表达率升高与COVID-19风险降低有关 (OR = 0.40, p = 0.05) 并与血清25 ((OH) D水平相反相关 (r = -0.61, p = 0.04).
- 较高的DEFA1-3表达显著降低了COVID-19风险 (OR = 0.184, p = 0.012).
- 血清维生素D水平和CCL20表达与COVID-19状态没有显著关联.
结论:
- 结果表明系统维生素D,局部VDR表达和天生的免疫反应在调节COVID-19易感性之间存在复杂的相互作用.
- 维生素D水平和组织特异性VDR信号似乎影响宿主对SARS-CoV-2感染的防御.
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