相关实验视频

Updated: Sep 9, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

影响结核病诊断延迟的因素

Ting Li^1,2, Yan Feng^1,2, Man Wang^1,2

¹Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China.

World journal of gastroenterology

|September 4, 2025

概括

在中国,近一半的患者被诊断为患有乳病. 血尿酸 (BUN) 含量升高是关键的危险因素,特别是在特定的患者群体中,强调了针对性查的必要性.

科学领域:

胃肠道学和自身免疫学
临床诊断和风险因素分析
自免疫性疾病的流行病学

背景情况:

乳病是一种由质引发的自身免疫性疾病,表现为疲劳和营养不足等多种症状.
非特异性表现往往导致显著的诊断延迟,增加骨质疏松症和淋巴瘤等并发症的风险.
长期延迟 (≥2年) 的CeD诊断会对患者的生活质量产生负面影响.

研究的目的:

确定在中国患者中诊断延迟的发生率.
识别与延迟CeD诊断相关的独立风险因素.
探索诊断延迟路径中介因素的作用.

主要方法:

从2017年开始诊断的166名中国CeD患者的临床记录的回顾性分析.
评估患者和医生相关的诊断延迟.
逻辑回归和限制立方线用于风险因素识别和非线性分析;中间因素的调解分析.

主要成果:

42. 2% 的 CeD 患者的诊断延迟超过 2 年; 18. 7% 的患者的诊断延迟超过 5 年.
血尿酸 (BUN) 的升高是诊断延迟的一个独立预测因素 (OR=1. 29),风险显著增加至4. 3 mmol/ L以上.
在女性,非古典性CeD,哈萨克族,没有维生素D缺乏/ 贫血或Marsh III病理患者中,BUN的风险效应更为明显.

结论:

较高的BUN水平是患有腹腔疾病的诊断延迟的重要预测因素.
与BUN相关的诊断延迟风险在性别,疾病亚型,种族和病理方面呈现异质性.
为缩短诊断时间,建议针对BUN≥4. 3mmol/ L的个体进行针对性查.

关键词:

血液中的尿素性疾病诊断时间延迟独立的风险因素有限制的立方线

更多相关视频

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

相关概念视频

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...

Factors Influencing Drug Absorption: Disease States and Pharmacology

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...

Other Disorders of Digestive System

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...