揭示仙:一种对抗慢性便秘的新方法
Xing-Lin Zeng1,2, Lian-Jun Zhu1,3, Yu Zhang3
1Clinical Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
World journal of gastroenterology
|September 4, 2025
概括
通过降低肠道细胞的氧化应激和亡,Xuanshen (XSD) 有效地治疗缓慢过渡性便秘 (STC). 这种传统中医药刺激了与核素红色素2相关的酸3-激酶/蛋白激酶B因子2路径,从而产生治疗效果.
科学领域:
- 胃肠病学
- 药理学
- 传统中国医学
背景情况:
- 慢过渡性便秘 (STC) 是一种功能性胃肠道疾病,治疗选择有限.
- 仙 (XSD) 是一种用于STC的传统中医药 (TCM) 配方,但其确切的作用机制尚未完全理解.
研究的目的:
- 阐明XSD在STC治疗中的治疗机制.
- 在STC大鼠模型中研究XSD对氧化应激,细胞亡和相关信号通路的影响.
主要方法:
- 使用洛佩拉胺诱导的STC在老鼠中的综合网络药理学,分子对接和体内研究.
- 通过便参数和肠道传输评估XSD疗效.
- 分析了结肠粘膜组织病理,粘素生产和关键蛋白质表达水平.
主要成果:
- 在大鼠中,XSD显著改善了STC症状,包括便和水分的增加.
- XSD治疗上调了诸如干细胞因子,C-kit,催化酶,超氧化脱酶,核因子红色素2相关因子2 (Nrf2) 和B细胞淋巴瘤2 (Bcl-2) 等保护性因子.
- XSD降低了亡的标志物,如分裂的亡酶-3,Bcl-2-关联的X蛋白 (Bax) / Bcl-2比率,以及亡蛋白,表明氧化应激和亡的减少.
结论:
- 通过减轻Cajal的间歇细胞中氧化应激诱导的亡,XSD有效治疗STC.
- 治疗机制涉及酸3-激酶 (PI3K) /蛋白激酶B (Akt) /核因子红色素2相关因子2 (Nrf2) 信号通路的激活.
- 通过其多重目标效应,XSD为STC提供了一个有前途的治疗策略.
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