空气污染与非酒精性脂肪肝疾病风险之间的关联:更新的元分析
Xu Zhang1, Xianzhao Yang1, Lanshuo Hu2
1Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Frontiers in public health
|September 4, 2025
概括
包括PM2.5和NO2在内的空气污染与非酒精性脂肪肝 (NAFLD) 的风险增加有关. 这种关联在发达国家和队列研究中更为明显.
科学领域:
- 环境健康
- 肝病学
- 流行病学
背景情况:
- 空气污染对环境健康构成重大风险.
- 新出现的证据表明空气污染物与非酒精性脂肪肝疾病 (NAFLD) 之间存在联系.
- 目前关于这种关联的研究结果不一致.
研究的目的:
- 系统地评估各种空气污染物暴露与发展NAFLD风险之间的关系.
- 提供有关空气污染和NAFLD的当前科学文献的综合分析.
- 确定影响NAFLD风险的特定污染物和研究特征.
主要方法:
- 在PubMed,Embase和Web of Science的系统文献搜索到2025年3月20日.
- 使用随机效应模型计算组合赔率 (OR) 和95%置信区间 (95%CI) 的元分析.
- 进行了子组分析,敏感性分析,并使用了漏斗图表和埃格尔测试来评估偏差和稳定性.
主要成果:
- 对超过4900万参与者的12项研究的分析显示,随着污染物水平的提高,NAFLD的风险增加.
- 每增加10μg/ m3的PM2. 5,PM10和NO2与NAFLD的几率显著增加有关.
- 对于PM2.5 (OR1.22) PM10 (OR1.07) 和NO2 (OR1.10) 的相关性更为明显.
- 臭氧 (O3) 和一氧化碳 (CO) 与NAFLD没有显著联系.
- 在发达国家,欧洲和队列研究中,小组分析显示了更强的关联.
结论:
- 这一元分析证实了特定空气污染物暴露与非酒精性脂肪肝疾病风险之间的积极关联.
- 颗粒物 (PM2.5,PM10) 和二氧化 (NO2) 是与NAFLD相关的主要污染物.
- 地理区域和经济发展水平似乎改变了空气污染与NAFLD关系的强度.
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