相关实验视频

Updated: Sep 9, 2025

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

超越血细胞:无细胞DNA在输血医学中的新兴作用

Jackson M Wahman¹, Rhoda X Hijazi¹, Elizabeth Duncan¹

¹Department of Physiology and Pharmacology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX, USA.

Journal of hematology

|September 4, 2025

概括

输血中的无细胞DNA (cfDNA) 可能会在受体中持续存在,可能导致免疫反应和基因组变化. 目前的血液处理不能去除cfDNA,因此需要改善输血安全措施.

科学领域:

* 输血医学
* 分子生物学
* 免疫学

背景情况:

* 无细胞DNA (cfDNA) 是循环中的碎片DNA,对诊断至关重要.
* 输血产品中的cfDNA提出了新的临床挑战.
* 捐赠者的cfDNA可能会导致接受者发生与输血相关的微化学反应.

研究的目的:

* 审查输血受体中供体cfDNA的持续性和免疫影响.
* 检查cfDNA基因组整合和免疫通路激活的可能性.
* 突出目前cfDNA去除中的白血减退的局限性.

主要方法:

*关于输血中的cfDNA的最新科学文献综合.
* 关于cfDNA持久性,整合和免疫效应的证据分析.
* 评估现有的血液处理技术,包括白血病减少.

主要成果:

* 供体cfDNA可以长期存在于输血受体中.
* cfDNA可能融入宿主基因组并改变表观遗传修饰.
* 天生的免疫通路,如Toll类受体,可以被cfDNA激活.
* 输血cfDNA中的环境或饮食DNA可能会影响免疫调节.
* 血红减少不能消除cfDNA或防止微化学反应.

结论:

* 捐赠者cfDNA存在潜在风险,包括免疫激活和基因组改变.
* 目前的血液处理方法不足以减轻cfDNA相关的风险.
* 进一步的研究和改进的血液处理对于输血安全至关重要.

关键词:

异构输血没有细胞的DNA 表观遗传学基因转移免疫激活微化学其他类型

更多相关视频

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Cell-Free DNA Integrity Analysis in Urine Samples

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

相关概念视频

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Blood Transfusion

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...