基于多光子显微镜的高血压诱导大动脉纤维重塑的三维定量评估:跨年龄的视角
Nannan Wang1,2, Rongli Zhang1,2,3, Anni Zhao1,2
1Research Center for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of China.
Royal Society open science
|September 4, 2025
概括
这项研究揭示了高血压如何通过先进的成像来改变大动脉纤维结构. 这些发现揭示了大动脉衰老和高血压的微观变化,有助于心血管疾病研究.
科学领域:
- 心血管科学
- 生物医学工程
- 老龄化研究
背景情况:
- 在全球范围内,高血压是导致心血管疾病的主要原因.
- 动脉纤维重塑对于高血压的发展至关重要,
- 在高血压期间,大动脉结构的微观变化尚不清楚.
研究的目的:
- 量化评估高血压诱导的大动脉纤维的微结构改造.
- 在高血压条件下研究与年龄有关的大动脉纤维结构变化.
- 探索大动脉部分对高血压反应的变化.
主要方法:
- 使用无标签多光子显微镜 (MPM) 来成像主动脉原和弹性纤维.
- 采用三维 (3D) 灰度共发生矩阵 (GLCM) 算法进行纹理分析.
- 从自发高血压的老鼠和Wistar-Kyoto对照组的样本中检查了三个年龄阶段和两个大动脉段.
主要成果:
- 确定了与高血压和年龄相关的3D GLCM纹理特征.
- 在微观结构层面上量化高血压诱导的大动脉重塑和加速的大动脉衰老.
- 腹部和胸部大动脉对高血压的反应呈异质.
结论:
- 联合MPM和3D GLCM方法为高血压诱导的大动脉微结构变化提供了新的见解.
- 这些发现阐明了与年龄相关的高血压和大动脉重塑的机制.
- 这项研究有助于了解心血管疾病的发病和潜在的治疗点.
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