在阿法西亚中,右侧三角体的网络可控性受损引起的变化
Harrison Stoll1, Apoorva Kelkar1, Peter E Turkeltaub2,3
1Department of Psychological and Brain Sciences, Drexel University, Philadelphia, PA, USA.
Neurobiology of language (Cambridge, Mass.)
|September 4, 2025
概括
在左半球中风后, 失言症患者表现出右半球语言处理的改变. 在右侧三角体 (rPTr) 中增加的网络控制与较少的语音错误相关,这表明其具有补偿作用.
科学领域:
- 神经科学
- 神经语言学
- 网络科学
背景情况:
- 左半球中风会破坏语言网络, 可能导致右半球的招募.
- 在中风后的语言处理中,右侧三角体 (rPTr) 的作用受到争议,其功能意义和对神经调节的反应有不同的证据.
- 白质连接可能会调解中风对语言网络功能的影响.
研究的目的:
- 调查左半球中风是否会改变右半球三角形 (rPTr) 的结构特征.
- 检查rPTr的网络控制特性与患有口音障碍的人的语言处理之间的关系.
主要方法:
- 使用网络控制理论 (NCT) 的措施,特别是边界可控性 (BC),以评估rPTr的通信集成能力.
- 在60个PWA和62个对照组之间,rPTr中的BC比较.
- 与PWA中的语义和语音语言性能相关的rPTr BC.
主要成果:
- 与对照组相比,患有失言症 (PWA) 的人在右侧三角形 (rPTr) 中表现出显著更高的边界可控性 (BC).
- 在图片命名任务中,较高的rPTrBC与语音错误的减少有关.
结论:
- 左半球中风诱导右半球区域的结构网络控制特性发生变化,包括rPTr.
- 在PWA中rPTr增加的BC可能反映出语言处理缺陷的补偿机制.
- 这些发现突显了结构性连接对于理解中风后语言恢复以及右半球区域的作用的重要性.
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