视神经头部的结构变化
Dania A Rahal1, Darrin A McFall1, Muhammad Z Chauhan1
1Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Clinical ophthalmology (Auckland, N.Z.)
|September 4, 2025
概括
视内注射 (IVI) 可以轻微增加视神经头部 (ONH) 的深度. 之前的IVI与这种变化有反向相关性,这表明与眼病进展相关的累积结构效应.
科学领域:
- 眼科 眼科
- 视网膜成像
- 大眼的研究
背景情况:
- 视网膜内注射 (IVI) 是常见的视网膜疾病的治疗方法.
- IVI对视神经头部 (ONH) 和布鲁赫膜开口 (BMO) 的急性解剖效应尚未完全理解.
- 鉴于ONH在眼中的作用,了解这些变化至关重要.
研究的目的:
- 在抗VEGF IVI后评估BMO和ONH坑深度的急性解剖变化.
- 调查影响这些解剖变化的因素,包括先前注射史.
主要方法:
- 在51名接受抗VEGF IVI的患者中进行前性研究.
- 在注射前和后进行高分辨率光学连贯性断层扫描 (OCT).
- 测量ONH坑深度和BMO变化
主要成果:
- 在IVI后,ONH孔深度平均增加31.57±24.36μm (p<0.001).
- 之前的IVI数量与坑深度的变化有显著的反向相关性 (r = -0.369,p = 0.004).
- 没有发现其他患者变量或内血压升高和穴位深度/BMO变化之间的显著关联.
结论:
- 玻璃内注射与ONH深度的轻微急性增加有关.
- 重复的静脉注射可能会对ONH结构产生累积影响.
- 这些结构变化可能与眼病的进展有关,因此需要进一步调查.
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