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相关概念视频

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
740
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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相关实验视频

Updated: Sep 9, 2025

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
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An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

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视神经头部的结构变化

Dania A Rahal1, Darrin A McFall1, Muhammad Z Chauhan1

  • 1Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Clinical ophthalmology (Auckland, N.Z.)
|September 4, 2025
PubMed
概括
此摘要是机器生成的。

视内注射 (IVI) 可以轻微增加视神经头部 (ONH) 的深度. 之前的IVI与这种变化有反向相关性,这表明与眼病进展相关的累积结构效应.

关键词:
没有深度药物注射在玻璃内视神经一个坑

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Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
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相关实验视频

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科学领域:

  • 眼科 眼科
  • 视网膜成像
  • 大眼的研究

背景情况:

  • 视网膜内注射 (IVI) 是常见的视网膜疾病的治疗方法.
  • IVI对视神经头部 (ONH) 和布鲁赫膜开口 (BMO) 的急性解剖效应尚未完全理解.
  • 鉴于ONH在眼中的作用,了解这些变化至关重要.

研究的目的:

  • 在抗VEGF IVI后评估BMO和ONH坑深度的急性解剖变化.
  • 调查影响这些解剖变化的因素,包括先前注射史.

主要方法:

  • 在51名接受抗VEGF IVI的患者中进行前性研究.
  • 在注射前和后进行高分辨率光学连贯性断层扫描 (OCT).
  • 测量ONH坑深度和BMO变化

主要成果:

  • 在IVI后,ONH孔深度平均增加31.57±24.36μm (p<0.001).
  • 之前的IVI数量与坑深度的变化有显著的反向相关性 (r = -0.369,p = 0.004).
  • 没有发现其他患者变量或内血压升高和穴位深度/BMO变化之间的显著关联.

结论:

  • 玻璃内注射与ONH深度的轻微急性增加有关.
  • 重复的静脉注射可能会对ONH结构产生累积影响.
  • 这些结构变化可能与眼病的进展有关,因此需要进一步调查.