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在有症状的隐形眼镜佩戴者中对 Lifitegrast 5% 眼镜溶液的临床评估

Marc-Matthias Schulze¹, Sarah E Guthrie¹, Brandon Ho^1,2

¹Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada.

Clinical ophthalmology (Auckland, N.Z.)

|September 4, 2025

概括

在两周内,Lifitegrast 5% 眼镜溶液显著改善了隐形眼镜的不适和干燥. 这种治疗改善了眼睛干燥的患者舒适的隐形眼镜佩戴时间和症状.

科学领域:

眼科眼科
视光学
药物有效性研究

背景情况:

有症状的隐形眼镜佩戴者通常会在一天结束时感到干燥和不舒服.
现有的治疗方法可能无法完全解决与隐形眼镜相关的多因素性质.
Lifitegrast 5% 眼液是治疗这些症状的一种潜在选择.

研究的目的:

评估5% lifitegrast 眼液在缓解白天干燥和不适的效果.
评估liftegrast对隐形眼镜佩戴者的生活质量和眼睛舒适性的影响.

主要方法:

开放式研究,涉及有症状的隐形眼镜佩戴者,在一天结束时显著干燥 (视觉模拟尺度 (VAS) ≥40).
在使用常规隐形眼镜期间,参与者每天两次注入5%的lifitegrast眼镜溶液.
与基线相比,评估结果包括干燥和不适的VAS得分,隐形眼镜干眼问卷-8 (CLDEQ-8) 得分和舒适的佩戴时间.

主要成果:

在2周内观察到白天干燥和不适的显著改善,持续了12周 (p< 0. 01).
报告严重干燥 (VAS ≥40) 的参与者百分比从基线下降到12周后的17%.
隐形眼镜干眼问卷-8分数和舒适的隐形眼镜佩戴时间显著改善,从6小时增加到9小时 (p<0.01).

结论:

在使用隐形眼镜的患者中,Lifitegrast 5% 眼液显著改善了干燥和不适的症状.
治疗效果,包括增加舒适的佩戴时间,在持续使用两周内迅速实现.
对于患有与隐形眼镜相关的眼睛干燥症的人来说,Lifitegrast是一种有价值的治疗选择.

关键词:

隐形眼镜隐形眼镜的不适隐形眼镜的症状眼睛干燥生命的花草眼细胞因子

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