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Updated: Apr 13, 2026

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在PLN-R14del小鼠中,SR结构的恢复,而不是循环,是PLN-ASO治疗的主要效应因素

Liu Sun1, Tim R Eijgenraam1, Carl Amilon2

  • 1Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Cardiovascular research
|September 4, 2025
PubMed
概括

在PLN-R14del小鼠中,通过恢复肉质网膜结构来改善心脏功能和寿命,而不是主要通过改变动力学.

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The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
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