抗胰岛素转化酶抑制剂与抗胰岛素受体阻断剂的比较有效性:多数据库目标试验模拟研究
在PubMed上查看摘要
概括
此摘要是机器生成的。与血管激素受体抑制剂 (ARB) 相比,血管激素转化酶 (ACE) 抑制剂与死亡和重大心血管不良事件的风险增加有关. 这表明仔细选择这些重要的心血管和保护药物至关重要.
科学领域
- 心血管医学
- 药理学
- 肝脏病学
背景情况
- 建议使用血管和受体抑制剂 (ACE) 进行心血管和保护.
- 对ACE抑制剂与ARBs对死亡率的长期疗效的比较尚未得到充分证实.
研究的目的
- 对所有原因死亡率和主要心血管不良事件的ACE抑制剂与ARBs的长期有效性进行比较.
- 为最佳选择血管激素-阿尔多斯特系统抑制剂提供证据.
主要方法
- 使用英国生物库和中国脏数据系统的多数据库队列研究.
- 针对新使用ACE抑制剂或ARB药物的倾向性评分匹配的目标试验模拟框架.
- 主要结局:五年全因死亡率;次要结局:主要心血管不良事件.
主要成果
- 开始服用ACE抑制剂与5年内因任何原因死亡的风险较高有关 (英国生物库:HR 1. 13;中国脏数据系统:HR 1. 12).
- 在两种数据库中,与ARB启动剂相比,开始服用ACE抑制剂的患者患有较大的心血管不良事件的风险.
- 这两大数据库的一致性强化了研究的结论.
结论
- 与ARB相比,开始使用ACE抑制剂的死亡率和主要心血管不良事件的风险更高.
- 这些发现强调在选择ACE抑制剂和ARB之间进行患者护理时需要仔细考虑.
- 这项研究为这些广泛使用的药物类别的相对安全性和有效性提供了宝贵的见解.
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