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在大麻和PrEP使用的交叉点评估炎症生物标志物:NCHAT-BIO研究的初步发现

Ethan Morgan^1,2, Thomas W McDade^3,4, Wendy Manning⁵

¹College of Nursing, The Ohio State University, Columbus, OH, USA.

Journal of acquired immune deficiency syndromes (1999)

|September 4, 2025

概括

使用大麻的暴露前预防 (PrEP) 患者的炎症减少. 然而,未使用PrEP的人没有观察到这种抗炎作用,这表明PrEP可能会增加炎症.

科学领域:

免疫学
公共卫生
药理学

背景情况:

之前的研究表明,艾滋病毒阳性大麻使用者的炎症减少,但艾滋病毒感染者的炎症并没有减少.
这项研究调查了暴露前预防 (PrEP) 对艾滋病毒阴性个体炎症标志物的影响.

研究的目的:

在艾滋病毒阳性成年人中检查PrEP使用,大麻使用和炎症生物标志物 (CRP,IL-6,EBV抗体) 之间的关联.
确定大麻使用是否改变了PrEP使用与炎症之间的关系.

主要方法:

来自NCHAT队列研究的数据分析,包括3,642名成年受访者.
通过干血斑点从573名参与者中收集生物数据 (CRP,IL-6,EBV抗体).
多变量回归分析以评估人口特征,PrEP使用,大麻使用和生物标志物之间的关系,调整混因素.

主要成果:

在调整的模型中,无论是终身还是当前的PrEP使用都与CRP,IL-6或EBV抗体水平无关.
在PrEP使用者和非使用者之间,大麻使用率没有差异.
在PrEP使用者中,大麻使用与较低的CRP水平有关 (B=-2.31;95%CI: -4.23, -0.40);在非PrEP使用者中没有发现这种关联.

结论:

预先发现,大麻使用可能会降低使用PrEP的个体的炎症,但不会降低不使用PrEP的个体的炎症.
这可能意味着PrEP可能会增加炎症,大麻中的大麻素/大麻二醇可能会减轻这种影响.
需要进一步的研究来证实这些假设,并阐明底层机制.

关键词:

预备剂炎症发生大麻

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