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母亲艾滋病毒状况对新生儿早期微生物群的影响

M Carolyn^1,2,3, Jonathan Strysko^1,2,4,5, One Bayani⁶

¹Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, U. S. A.

Journal of the Pediatric Infectious Diseases Society

|September 4, 2025

概括

暴露于艾滋病毒的新生儿的早期新生儿微生物组与母亲的艾滋病毒状况没有显著差异. 然而,母体艾滋病毒诊断的时间会影响微生物组成,这表明微生物组的变异会在以后出现.

科学领域:

微生物组研究
新生儿健康
艾滋病毒对母亲的影响

背景情况:

母亲的艾滋病毒状况会影响孩子的健康状况,可能是通过微生物组的破坏.
暴露于艾滋病毒 (HE) 的新生儿早期的新生儿微生物组仍未得到充分研究.

研究的目的:

分析暴露于艾滋病毒和未暴露于艾滋病毒的新生儿早期微生物组合.
研究母亲艾滋病毒诊断时间对新生儿微生物组发展的影响.

主要方法:

来自博茨瓦纳57名新生儿的鼻腔,皮肤和直肠样本的16S核糖核酸序列 (33%的HE).
在出生后72小时内分析微生物群的β多样性和种群数量.

主要成果:

根据母亲的艾滋病毒状况,微生物群多样性没有显著的总体差异.
在考虑母体艾滋病毒诊断时间时,鼻腔和皮肤微生物群的多样性出现了显著差异.
在怀孕前被诊断为艾滋病毒感染的母亲所产生的新生儿与未感染艾滋病毒的新生儿具有微生物组的相似性.

结论:

仅仅由母亲的艾滋病毒状况而言,新生儿早期的微生物组合并没有显著改变.
艾滋病毒诊断的时间对新生儿微生物组的形成起着至关重要的作用.
与艾滋病毒相关的微生物组变化可能在婴儿期晚些时候变得更加明显,突出显示早期暴露的影响.

关键词:

艾滋病毒全球卫生微生物组新生儿感染性疾病

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