社区卫生工作者和新兴成年人移动健康转换状细胞疾病治疗 (COMETS) 试验:随机对照试验协议
Tanisha D Belton1, Caren M Steinway2,3, Olivia Teng2
1PolicyLab, Division of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
JMIR research protocols
|September 4, 2025
概括
这项研究比较了在护理过渡期间患有状细胞疾病的年轻人的移动健康应用程序和社区卫生工作者. 这两种干预措施都旨在改善生活质量和减少住院治疗.
科学领域:
- 血液学
- 数字健康
- 公共卫生
背景情况:
- 从儿科到成人状细胞疾病 (SCD) 护理的过渡是死亡率和医疗利用率增加的关键时期.
- 患有SCD的新成年人面临的挑战包括分散的护理,导航成人系统和增加的自我管理需求.
- 目前对SCD的过渡支持是有限的,这凸显了对有效干预的需要.
研究的目的:
- 将移动卫生 (mHealth) 和社区卫生工作者 (CHW) 的干预与新生成人SCD标准护理的有效性进行比较.
- 评估这些干预措施对与健康有关的生活质量,急性护理使用和过渡成功的影响.
- 为患有SCD的年轻人提供可扩展和可持续的过渡支持计划.
主要方法:
- 社区卫生工作者和新兴成年人移动健康转换状细胞疾病治疗 (COMETS) 试验是一个多中心,三臂随机对照试验.
- 375名患有SCD的新生成人 (17至25岁) 被随机分配到CHW支持,mHealth (iManage/ THRIVE 2.0) 或增强常规护理.
- 参与者进行了18个月的跟踪,主要结果是自我报告的与健康有关的生活质量 (PedsQL SCD模块).
主要成果:
- COMETS试验的招募工作已经完成,已有405名参与者报名.
- 数据收集正在进行中,预计将在2024年11月结束.
- 这项研究正在解决SCD年轻人的过渡干预研究的关键缺口.
结论:
- 该试验将提供关于CHW和mHealth干预措施对SCD转型的比较有效性的关键证据.
- 预计这些发现将为改进,可扩展和可持续的过渡支持计划的开发提供信息.
- 成功的过渡干预可以提高生活质量,减少急性护理需求,并促进患有SCD的年轻人获得更好的长期结果.
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