全球趋势和急性肝炎E负担的健康不平等:一个结合点回归和跨国不平等分析,1990-2021年
Deliang Huang1,2, Zhibin Zhu1,2, Jinghan Peng1,2
1Department of Liver Diseases, The Third People's Hospital of Shenzhen, Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
Journal of viral hepatitis
|September 4, 2025
概括
全球急性肝炎E (AHE) 负担有所降低,但发达国家的发病率和流行率正在上升. 较低社会经济水平的地区仍然承受较高的AHE负担,凸显了持续存在的健康不平等.
科学领域:
- 流行病学
- 全球健康
- 健康经济学
背景情况:
- 严重的乙型肝炎 (AHE) 构成了全球重大卫生挑战,影响不同社会经济状况的地区.
- 了解AHE的长期趋势和社会经济差异对于有效的公共卫生干预至关重要.
研究的目的:
- 分析从1990年到2021年的AHE负担 (发病率,流行率,死亡率,DALY) 的时间趋势.
- 量化不同社会经济层面的AHE负担中的健康不平等 (社会人口指数 - SDI).
- 鉴别疾病流行病学方面的变化,特别是关于发达地区和发展中国家的变化.
主要方法:
- 利用了2021年全球疾病负担研究的数据.
- 采用结合点回归分析来确定AHE指标的重大趋势.
- 进行了跨国不平等分析,以评估AHE负担在SDI五分位数中的分布.
主要成果:
- 全球AHE发病率,流行率,死亡率和DALY率从1990年至2021年显著下降.
- 尽管总体下降,但AHE病例的绝对数量继续增加.
- 在AHE疾病率和SDI水平之间观察到一个反向的相关性,较低的SDI国家承担的负担不成比例.
- 最近的趋势显示,高中度SDI国家的发病率和患病率在增加,高中度SDI国家的死亡率和DALY在下降,高中度SDI的国家在回升.
- 随着时间的推移,各国之间的AHE负担的不平等程度有所减少,但差异仍然存在.
结论:
- 在全球范围内,肝炎E病毒的发病率有所下降,但仍存在严重的健康差异.
- 相关的流行病学转变表明,在发达地区 (高和中等SDI) 出现了AHE的复苏,同时在发展中国家 (低SDI) 持续存在负担.
- 持续监测和适应性策略对于管理全球不断变化的AHE环境至关重要.
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