骨激素变化与治疗引起的体重增加之间的抗逆转录病毒特异关联
Niyati Patel1, Bryan Dulion1, Itzel Lazcano1
1Department of Anatomy & Cell Biology and Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL.
AIDS (London, England)
|September 4, 2025
概括
开始抗逆转录病毒治疗 (ART) 的HIV患者的体重增加与骨源激素的变化有关,特别是低碳化骨素 (ucOCN) 和脂素-2 (NGAL). 这种关联因使用的特定ART疗法而异.
科学领域:
- 内分泌学
- 艾滋病毒/艾滋病研究
- 药理学
背景情况:
- 开始抗逆转录病毒治疗 (ART) 的HIV患者经常出现体重增加的副作用.
- 与ART相关的体重增加背后的确切生物机制尚不完全理解.
- 骨源激素与代谢调节有关,这表明它们可能在ART诱导的体重变化中起作用.
研究的目的:
- 在开始ART的未经治疗的PWH中,研究特定的骨源激素与体重增加之间的关联.
- 确定这些关联是否针对不同类型的抗逆转录病毒药物.
主要方法:
- 来自ACTG研究A5260s的血样本分析,涉及未经治疗的PWH,使用ATV/r,DRV/r或RAL启动TDF/FTC.
- 在基线和48周内测量血低碳酸骨素 (ucOCN),利波卡林-2 (NGAL) 和硬质素水平.
- 用线性回归模型评估激素水平和体重变化之间的关系,调整为共变量.
主要成果:
- 增加的ucOCN和减少的NGAL水平与接受ART的PWH体重变化有显著的相关性.
- 斯克莱洛斯水平与体重变化没有显著关联.
- 主要在接受基于拉尔特格拉维尔 (RAL) 的ART治疗的参与者中观察到ucOCN和NGAL与体重变化的关联,而不是基于蛋白酶抑制剂的治疗方案 (ATV/ r,DRV/ r).
结论:
- 骨源激素,特别是ucOCN和NGAL,与PWH中ART诱导的体重增加有关.
- 这些激素与体重增加之间的关系受特定抗逆转录病毒药物治疗方案的影响.
- 在调整后,利波卡林-2 (NGAL) 仍然与RAL患者的体重增加有显著的关联,这表明潜在的ARV特异性机制.
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