超分辨率超声波成像用于评估子VX2模型中的微血管结构和血液动力学变化
Chaonan Chen1,2, Qianqian Zeng1, Sitong Chen1
1Department of Interventional Ultrasound, The Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China.
Journal of cancer research and therapeutics
|September 4, 2025
概括
超分辨率超声波 (SR-US) 有效地可视化和量化瘤微血管,与组织病理学有很好的相关性. 这种先进的成像技术为瘤生长过程中的微血管变化提供了宝贵的见解.
科学领域:
- 医学成像
- 超声波技术
- 癌症研究
背景情况:
- 在微观层面对瘤血管系统进行非侵入性成像对于了解瘤生长至关重要.
- 超分辨率超声波 (SR-US) 提供了对微血管的高分辨率可视化的潜力.
研究的目的:
- 研究SR-US在子VX2瘤模型中可视化和量化微血管的可行性.
- 将SR-US成像能力与传统超声波和对比增强超声波 (CEUS) 进行比较.
- 使用SR-US参数评估血液动力学变化及其与瘤进展的相关性.
主要方法:
- 建立了九个子VX2瘤模型.
- 在多个时间点获取常规的US,CEUS和SR-US图像 (第5,8,14天).
- 使用皮尔森相关性,与组织病理学微血管密度 (MVD) 相关的SR-US导出血管密度 (VD).
主要成果:
- 与CEUS相比,SR-US提供了更高的分辨率,可视化微容器到105.2±7.5μm.
- 在SR- US静脉疾病和组织病理性MVD之间观察到强烈的正相关性 (r = 0. 82).
- SR-US参数显示出与瘤生长阶段相对应的显著微血管变化,包括血管像素的增加以及速度和碎形尺寸的改变.
结论:
- 定量SR-US是评估瘤进展过程中的微血管变化的宝贵工具.
- 通过SR-US可进行瘤新血管的非侵入性功能成像.
- 这项研究表明SR-US在临床前瘤研究中的潜力.
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