具有或没有先前COVID-19感染的人群中对无活化SARS-CoV-2疫苗的幽默免疫反应:长度队列研究
Shuang Zhang1,2, Xiaoman Jiang1,2, Changhui Du1,2
1Chengdu Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical Sciences, Chengdu, China.
Viral immunology
|September 4, 2025
概括
两个疫苗剂量可以提高COVID-19原始个体的抗体,而康复的个体可能只需要一剂. 随着时间的推移,抗体水平下降,影响疫苗的长期有效性.
科学领域:
- 免疫学
- 疫苗学
- 流行病学
背景情况:
- 了解对SARS-CoV-2疫苗的幽默免疫反应对于公共健康至关重要.
- 之前的COVID-19感染可能会影响疫苗诱导的抗体动态.
- 对抗体水平的长度评估可以了解疫苗的耐用性.
研究的目的:
- 评估抗 (抗S) 和抗核体 (抗N) 抗体反应的动态.
- 为了比较SARS-CoV-2原先感染者和经过不活化疫苗接种后康复的患者的免疫反应.
- 调查影响抗体水平的因素,包括年龄,性别和并发症.
主要方法:
- 一个长度队列研究,包括165名先前和38名COVID-19康复参与者.
- 使用两剂非活化SARS-CoV-2疫苗接种方案.
- 在基线和疫苗接种后多个时间点对抗S和抗N抗体水平的分析.
主要成果:
- 在第二次剂量后,原始参与者显示抗S血清阳性 (96. 23%) 和峰值标位增加.
- 康复的参与者在第一剂后的抗S水平显著上升,而第二剂的提升幅度很小.
- 第二剂后6个月抗体水平下降;年龄,性别和并发症影响了抗体反应.
结论:
- 对于以前没有接种过的个体,两剂疫苗是有效的;对于已康复的个体,一剂可能是足够的.
- 抗体水平的下降需要进一步研究疫苗诱导的免疫持久性.
- 根据先前的感染状况和人群特征,需要定制免疫策略.
相关概念视频
Vaccinations
45.3K
Overview
45.3K
Immunological Memory
4.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
4.7K
Humoral Immune Responses
75.5K
Overview
75.5K
Active versus Passive Immunity
3.6K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
3.6K
Cross-reactivity
31.5K
Overview
31.5K
Cells of the Adaptive Immune Response
4.0K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
4.0K


