梅克尔分泌体:儿童和成人之间的临床特征差异
N Srisan1, P Songsiri2,3, S Liukitithara3
1Department of Surgery, Faculty of Medicine, Chulalongkorn University & King Chulalongkorn Memorial Hospital, Bangkok, 10330, Thailand. nimmita.s@chula.ac.th.
Pediatric surgery international
|September 4, 2025
概括
这项研究比较了儿童和成人的梅克尔分泌体 (MD) 的临床特征. 在儿童中,下肠道出血很常见,而在成年人中,管炎更为频繁,支持偶尔的MD切除.
科学领域:
- 胃肠病学
- 儿童手术
- 外科病理学
背景情况:
- 梅克尔 (Meckel's diverticulum,简称MD) 是小肠的一个先天性异常.
- 在儿童和成人群体中,MD的临床表现和治疗策略可能有很大差异.
- 了解这些差异对于优化患者治疗结果至关重要.
研究的目的:
- 描述和比较梅克尔分离体的临床特征.
- 分析儿童与成人的人口统计数据,临床表现,调查,治疗,组织病理和术后并发症.
主要方法:
- 在2002年至2021年期间,对123名被诊断患有梅克尔分泌体 (MD) 的患者进行了回顾.
- 收集的数据包括人口统计,临床表现,诊断调查,治疗方式,组织病理发现和术后并发症.
- 儿童和成人患者队列之间的发现比较.
主要成果:
- 在儿童中,下胃肠道出血是最常见的症状 (52. 1%),而分泌体炎在成年人中最常见 (46. 7%).
- 麦克尔扫描显示出高灵敏度 (95%) 在诊断出血的儿童中.
- 在切除的MD标本中,有27.4%的胃外组织被发现,并且在症状和偶然发现的MD之间没有明显的术后并发症差异.
结论:
- 在儿童 (下肠道出血) 和成年人 (椎炎) 之间,梅克尔椎的主要临床表现不同.
- 梅克尔扫描是一种宝贵的诊断工具.
- 在无症状的多发性硬化病例中,有显著比例的异卵性胃组织存在,支持预防性切除偶然发现的多发性硬化病.
相关概念视频
Esophageal Strictures-II: Clinical Features and Management
155
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
155
Appendicitis-I: Introduction
589
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
589
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
51
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
51
Mitral Stenosis II: Clinical features and Diagnostic Tests
36
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
36
Esophageal Varices-II: Clinical Features and Management
133
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
133
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
3.6K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.6K


