血代谢物,代谢风险评分和结直肠癌风险:前性队列研究
Ying Deng1,2, Miaomiao Yang1, Panxin Peng3
1Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, Guangdong, People's Republic of China.
European journal of epidemiology
|September 4, 2025
概括
一项新的研究显示,特定的血液代谢物和代谢风险评分 (MRS) 与更高的结直肠癌 (CRC) 风险有关. 保持健康的代谢物水平和生活方式对于预防CRC至关重要.
科学领域:
- 代谢学
- 癌症流行病学
- 基因组学
背景情况:
- 结肠直肠癌的危险因素需要进一步阐明,特别是代谢物和生活方式的作用.
- 了解新陈代谢和生活方式之间的相互作用是有效的CRC预防策略的关键.
研究的目的:
- 研究血代谢物,代谢风险评分 (MRS) 和CRC风险之间的关联.
- 探索MRS和生活方式因素对CRC发展的联合影响.
- 通过单细胞RNA测序确定参与CRC进展的关键代谢途径.
主要方法:
- 这是一项针对82514名英国生物库参与者的前性队列研究,其中包含了血代谢物数据.
- 使用LASSO- COX和随机森林进行代谢物选择,并使用Cox回归进行MRS构造和风险关联分析.
- 分析单细胞RNA测序数据以确定与代谢相关的基因和CRC进展的途径.
主要成果:
- 6代谢物MRS与CRC风险的增加显著相关 (HR=1. 39),特别是在近端结肠癌 (HR=1.51).
- 观察到MRS和生活方式因素 (睡眠,吸烟,饮食) 与CRC风险增加之间存在关联.
- 这些代谢途径包括酸,胺和氨酸,都与从正常肠道粘膜转变为CRC有关.
结论:
- 预诊代谢物和发育的MRS是增加CRC风险的重要预测因素,特别是在近端结肠癌中.
- 即使有健康的生活方式因素,MRS高的人面临CRC风险升高.
- 建议维持正常的代谢物水平,并采取健康的生活方式来预防CRC.
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