自闭症成年人的焦虑和抑郁的测量:在可行性研究中的诊断和查工具之间的一致性
Annabelle M Mournet1, Linnea A Lampinen1, Lauren A Pepa1
1Rutgers, The State University of New Jersey, Piscataway, USA.
Journal of autism and developmental disorders
|September 4, 2025
概括
这项研究比较了自闭症成年人的焦虑和抑郁的诊断工具. 最好的估计临床诊断仍然是黄金标准,
科学领域:
- 神经发育障碍
- 临床心理学
- 精神病诊断
背景情况:
- 自闭症成年人往往会同时出现焦虑和抑郁症.
- 准确的诊断对于有效的治疗和临床试验至关重要.
- 现有的查和诊断工具需要在自闭症患者群体中进行验证.
研究的目的:
- 评估PHQ- 9,GAD- 7,ASR和ADIS- 5与自闭症成年人的最佳临床诊断 (BECD) 的一致性.
- 评估这些工具用于诊断严重抑郁症 (MDD) 和普遍焦虑症 (GAD) 的可靠性.
- 根据自闭症成年人的诊断实践和研究方法.
主要方法:
- 来自可行性治疗研究的基线和干预后数据.
- 使用统计分析,包括类间相关系数,AUC,灵敏度和特异性.
- 在不同临床切线水平上对比多种诊断仪器.
主要成果:
- 在DSM-5 (ADIS-5) 的焦虑和相关障碍面试表显示出与MDD和GAD的BECD在基线很强的一致性.
- 在焦虑症方面,GAD-7轻度切断值与BECD具有很高的一致性.
- PHQ-9中度切断线与BECD和ADIS-5MDD诊断最一致.
结论:
- 简短的查工具有效地确定潜在的焦虑和抑郁症状.
- 需要进一步的研究来规范临床诊断面试,如自闭症患者的ADIS-5.
- 最好估计的临床诊断 (BECD) 应该是对自闭症成年人同时出现疾病的研究的黄金标准.
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