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在活体影子和体外照明中:胚胎在子宫内膜异位症中的早期旅程

Grzegorz Mrugacz¹, Aleksandra Mospinek², Maria Modrzyńska-Olejniczak²

¹Center for Reproductive Medicine Bocian, Białystok Branch, 26 Akademicka St., 15-267 Białystok, Poland.

|September 4, 2025

概括

子宫内膜异位症通过炎症和氧化应激影响生育能力,影响卵子和胚胎质量. 在体外受精 (IVF) 显示出不同的成功, 但新的AI和免疫调节策略为改善患者护理提供了希望.

科学领域:

生殖内分泌学
免疫学
遗传学

背景情况:

宫内膜异位症对女性生育具有复杂的挑战, 包括慢性炎症,氧化应激和解剖学扭曲.
这些因素对卵细胞质量,胚胎发育和成功的植入有不利影响,使自然受孕复杂化.
在体外受精 (IVF) 提供了一个可控的环境来缓解与子宫内膜异位症相关的某些体内生育障碍.

研究的目的:

系统地审查子宫内膜异位症对卵细胞功能障碍和试管婴儿结果的影响.
评估目前和新兴的改善子宫内膜异位症患者的生育能力的策略.
识别与子宫内膜异位症相关的不孕症的个性化预后和有针对性的治疗方法的差距.

主要方法:

专注于子宫内膜异位症,卵细胞质量,胚胎发育,植入和试管婴儿结果的系统文献审查.
关于子宫内膜异位症相关不孕症机制的证据分析,包括炎症和氧化途径.
探索创新技术,如人工智能驱动的胚胎选择,单细胞奥米克和免疫调节.

主要成果:

子宫内膜异位症与卵细胞质量受损和胚胎发育减弱有关,导致试管婴儿成功率降低.
在子宫内膜异位症患者的试管婴儿结果是可变的,受疾病严重程度和特定治疗方案的影响.
人工智能胚胎选择和免疫调节疗法等新兴技术显示出提高试管婴儿成功的潜力.

结论:

尽管有进展,但与子宫内膜异位症相关的不孕症的个性化预后和向治疗仍需要进一步发展.
诸如人工智能,单细胞奥米克和免疫调节等创新工具为改善生育结果提供了有希望的途径.
一种以患者为中心的方法, 将科学证据与个性化护理结合起来, 对于治疗子宫内膜异位症和不孕症至关重要.

关键词:

胚胎形态动力学子宫内膜异位症在体外受精 (IVF)不孕症卵细胞质量氧化应激转录组学

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