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氧化应激和抗氧化机制在癌症发展和进展中的相互作用
Klaudia Jomova1, Suliman Y Alomar2, Richard Valko2
1Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74, Nitra, Slovakia.
Archives of toxicology
|September 4, 2025
概括
反应性氧物种 (ROS) 在癌症中具有双重作用,促进瘤生长和进展. 抗氧化剂也表现出复杂的效果,强调需要有针对性的治疗策略.
科学领域:
- 细胞生物学
- 生物化学
- 癌症学
背景情况:
- 在生理水平 (氧化应激) 上由活性氧物种 (ROS) 维持的细胞氧化平衡对于正常功能至关重要.
- 导致氧化应激, 导致癌症等慢性疾病.
- 包括超氧化离子基 (O2•−) 和过氧化 (H2O2) 在内的ROS是各种细胞系统产生的关键信号分子.
研究的目的:
- 研究活性氧物种 (ROS) 和抗氧化剂在癌症进展中的双重作用.
- 了解ROS如何影响瘤发展的不同阶段,包括扩散,入侵和转移.
- 研究瘤细胞调节ROS水平的机制以及对治疗策略的影响.
主要方法:
- 对癌症中ROS信号的现有文献的审查.
- 分析ROS对细胞过程的影响,如DNA损伤,上皮细胞转化为介质细胞 (EMT) 和瘤微环境 (TME) 的形成.
- 检查抗氧化网络的调节,包括NRF2和特定抗氧化酶的作用.
主要成果:
- 通过影响免疫细胞,新陈代谢和DNA损伤 (例如8-oxo-dG),ROS可以促进瘤的开始和进展.
- 过氧化 (H2O2) 驱动EMT并塑造TME,而过度的ROS可以诱导衰老或亡.
- 像谷氨 (GSH) 和NRF2这样的抗氧化剂对于癌细胞的生存至关重要,而像Mn-SOD (SOD2) 这样的酶则表现出环境依赖的作用.
结论:
- 在癌症治疗中,ROS和抗氧化剂的双重性提出了复杂的挑战和机遇.
- 了解氧化还原值和抗氧化网络对于开发有效的抗癌策略至关重要.
- 针对ROS介导途径和氧化还原平衡对未来的癌症治疗具有前景.
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