在儿童重症监护室治疗迷幻症的抗精神病药物:系统性审查
Francesca Cavagnero1, Annalisa Salerno1, Chiara Marchegiani Rizzolli1
1Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.
Paediatric drugs
|September 4, 2025
概括
在 PICU 中治疗儿科 Delirium 的药理疗法具有可变的疗效和潜在的安全问题,如 QTc 延长和 dystonia. 进一步的研究对于基于证据的儿科妄想治疗至关重要.
科学领域:
- 儿童重症监护
- 药理学
- 系统审查
背景情况:
- 儿科狂妄症 (PD) 在儿科重症监护室 (PICU) 很常见,
- 它与包括长时间住院和增加死亡率在内的不良结果有关.
- 目前的治疗指南优先考虑非药物疗法,药物使用证据有限.
研究的目的:
- 在PICU环境中系统地审查PD药物治疗的疗效和安全性.
- 确定常用的药物及其在治疗儿科妄想中的有效性.
- 评估与这些药物干预相关的不良事件.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 在主要数据库 (PubMed,Embase,Scopus等) 进行了搜索. 在2024年2月之前进行研究.
- 包括的研究重点是儿童患者 (1个月至18岁) 在PICU诊断患有PD并接受药物治疗.
主要成果:
- 分析了10项涉及283名患者的回顾性研究;没有发现RCT.
- 最常使用的药物是奎蒂亚平,瑞斯比和哈洛皮多尔.
- 在一项研究中,olanzapine 显示出显著的症状改善;其他研究显示出趋势. 这些不良事件包括QTc延长和 dystonia.
结论:
- 在PICU中治疗PD的药理疗法具有可变的疗效,并且与部分患者的不良反应有关.
- 研究质量有限,样本规模小,缺乏复制,阻碍了最终的结论.
- 需要进一步进行高质量的研究,以建立基于证据的小儿狂妄症药理学策略.
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