Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.5K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Parameter response mapping does not enhance the correlations of conventional CT quantitative metrics with lung function and subjective symptoms in chronic obstructive pulmonary disease.

Quantitative imaging in medicine and surgery·2026
Same author

Tuning Reaction Pathways via Symmetric Fluorination Enables High-Temperature and High-Voltage Electrolytes.

Angewandte Chemie (International ed. in English)·2026
Same author

Oral liver-targeted delivery systems for anti-hyperglycemic therapy: From passive to active targeting strategies.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Dipole Reorientation Induced Temperature-Dependent Solvation Structure in Low-Temperature Sodium Metal Batteries.

ACS nano·2026
Same author

Machine learning-based models using preoperative imaging and clinical data to predict intraoperative rebleeding and functional recovery in intracerebral hemorrhage patients: a multicenter study.

Journal of neurosurgical sciences·2026
Same author

Data-driven intelligent carbonization unifies diverse biomass into high-performance hard carbon negative electrodes.

Nature communications·2026
Same journal

Integrated structure-based and fragment-guided design of isonicotinic acid derivatives as potential KDM4A inhibitors: an in silico study.

Journal of computer-aided molecular design·2026
Same journal

Coumarin-based small molecules for diabetes management: rational design, computational studies, synthesis, and biological evaluation.

Journal of computer-aided molecular design·2026
Same journal

Quantitative structure-activity relationship characterization and modeling of length-varying bioactive peptides.

Journal of computer-aided molecular design·2026
Same journal

Prot-ΔΔG: Prediction of protein-protein binding affinity changes upon mutations with pre-training strategies.

Journal of computer-aided molecular design·2026
Same journal

Computational exploration and in vitro validation of anti-quorum sensing potential of phytochemicals from Coleus amboinicus.

Journal of computer-aided molecular design·2026
Same journal

Exploring the HNE-inhibitory potential of in silico selected Moringa oleifera defense proteins.

Journal of computer-aided molecular design·2026
查看所有相关文章

相关实验视频

Updated: Sep 9, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.0K

基于通用扩散模型的A类蛋白质生成

Tianqian Zhou1, Shibo Zhang1, Huijia Song1

  • 1College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China.

Journal of computer-aided molecular design
|September 4, 2025
PubMed
概括
此摘要是机器生成的。

这项研究引入了高级蛋白质设计的新型通用扩散模型,使灵活生成功能性蛋白质序列. 该方法成功地产生了高亲和度衍生物A_005,证明了其药物开发潜力.

关键词:
扩散模型生成型号蛋白质的设计进行查

更多相关视频

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.0K
Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
08:55

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials

Published on: June 25, 2018

8.1K

相关实验视频

Last Updated: Sep 9, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.0K
Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.0K
Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
08:55

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials

Published on: June 25, 2018

8.1K

科学领域:

  • 生物技术和生物信息学
  • 计算生物学和蛋白质设计
  • 生命科学中的生成模型

背景情况:

  • 生成模型对于药物开发,疫苗研究和生物催化剂中的蛋白质设计至关重要.
  • 传统的扩散模型因依赖高斯噪声来生成序列而受到限制.
  • 生物技术的进步需要更灵活和更适应的蛋白质设计工具.

研究的目的:

  • 提出和验证用于增强蛋白序列生成的通用扩散模型.
  • 在蛋白质设计灵活性方面克服传统扩散模型的局限性.
  • 证明该模型在设计具有高亲和力的功能蛋白质方面的能力.

主要方法:

  • 使用一热编码编码蛋白质序列,并通过通用扩散模型进行处理.
  • 使用AlphaFold预测生成的蛋白质的三级结构.
  • 序列选择涉及使用PyMOL进行结构对齐和骨干距离计算,随后进行实验性亲和度测试.

主要成果:

  • 一般化扩散模型产生了与目标具有高度结构和功能相似性的新型蛋白序列.
  • 一个衍生序列,A_005,表现出非常高的亲和力与亲蛋白A.
  • A_005显示了令人满意的分离和关联率,验证了该模型的有效性.

结论:

  • 一般化扩散模型为蛋白质设计提供了灵活和可适应的方法.
  • 这种方法有效地产生具有所需结构和功能特性的蛋白质序列.
  • 这些发现为生物医学和药物开发的未来应用提供了坚实的基础.