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在PGT-A患者中,AMH水平与胚胎积率之间的相关性:一项回顾性研究

Shufang Tang¹, Panpan Zhao², Kaixuan Sun²

¹Department of Reproductive Medicine, Postgraduate Training Base of Jinzhou Medical University (General Hospital of Northern Theater Command), No. 83, Wenhua Road, Shenhe District, Shenyang, 110016, China.

Journal of assisted reproduction and genetics

|September 4, 2025

概括

在接受植入前基因检测 (PGT-A) 的患者中,较低的抗Müllerian激素 (AMH) 水平与胚胎无体积的风险增加有关. 这表明卵巢储备会影响卵细胞质量,并影响辅助生殖的决定.

科学领域:

生殖内分泌学
人类胚胎学
不孕症研究

背景情况:

抗穆勒激素 (AMH) 是卵巢储备的一个关键指标.
胚胎形是植入失败和流产的主要原因.
在植入前基因检测 (PGT-A) 中,需要进一步阐明AMH水平与形状风险之间的准确关系,特别是非线性影响.

研究的目的:

在接受PGT-A的患者中,研究抗穆勒尔激素 (AMH) 水平与胚胎形发生率之间的关联.
探讨AMH对形瘤风险的非线性关系和潜在值影响.
在对混因素进行调整后,评估AMH作为形形成的独立风险因素.

主要方法:

对819个PGT-A周期进行了回顾性分析.
使用受限立方脊柱 (RCS) 分析来检查AMH和动质积分率之间的剂量反应关系.
调整了潜在的混因素,包括女性年龄,晚期母亲年龄 (AMA),复发性自发性流产 (RSA) 和复发性植入失败 (RIF).

主要成果:

在不同AMH群体中观察到受精率,胚胎质量和卵率的显著差异.
在AMH含量与胚胎形发生率之间发现了统计学意义上的非线性关系.
观察到一个值效应:对于AMH水平≤2. 54 ng/ ml,AMH下降1单位与阳性无体积率 (≥50%) 的风险增加有关.

结论:

即使考虑到年龄和其他因素,抗穆勒尔激素 (AMH) 也是PGT-A群体中胚胎积症的重要独立危险因素.
较低的AMH水平与更高的胚胎无体积的风险相关,这表明卵巢储备和卵细胞质量之间存在联系.
这些发现为辅助生殖技术的个性化治疗策略提供了宝贵的见解.

关键词:

没有体抗穆勒尔激素在植入前检测体积

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