工业化饮食模式与FTO RS9939609基因多态儿童心脏代谢风险因素之间的关联
Bhreendda' Hary Dy Luar Prates Kiepper1, Francilene Maria Azevedo1, Aline Carare Candido1
1Department of Nutrition and Health, Postgraduate Program in Nutrition Science, Federal University of Viçosa, Viçosa, Brazil.
Molecular nutrition & food research
|September 4, 2025
概括
暴露于工业化饮食中的FTO基因多态儿童患有心脏代谢风险增加. 针对饮食模式的营养策略对于预防这一脆弱群体至关重要.
科学领域:
- 儿童营养
- 遗传流行病学
- 心脏代谢健康
背景情况:
- 饮食模式显著影响心脏代谢风险,特别是在基因敏感的儿童中.
- 脂肪和肥胖相关的基因与肥胖和代谢功能障碍有关.
- 了解基因与饮食的相互作用对于个性化儿科健康策略至关重要.
研究的目的:
- 研究4至7岁儿童不同饮食模式与心脏代谢风险因素之间的关联.
- 在FTO基因多态性方面专门研究这些关联 (rs9939609).
- 确定可能加剧遗传倾向儿童心脏代谢风险的特定饮食模式.
主要方法:
- 涉及258名儿童 (4至7岁) 的截面研究.
- 评估身体组成 (DEXA),生化标志物和血压.
- 用多重线性回归分析对FTO rs9939609多态的基因定型和饮食模式的分析
主要成果:
- "工业化"饮食模式与FTO多态儿童的甘油三指数 (TyG) 和甘油三指数显著增加有关.
- "牛奶和巧克力牛奶"模式与携带风险等位基因的儿童的TyG指数存在关联.
- 在研究队列中观察到FTO多态的流行率为20. 2%.
结论:
- 坚持"工业化"饮食模式与患有FTO多态基因的儿童心脏代谢风险增加有关.
- 这些发现强调了定制营养干预措施在遗传敏感儿童中减轻心脏代谢风险的重要性.
- 对基因与饮食相互作用的进一步研究可以为儿童肥胖和代谢疾病的预防策略提供信息.
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