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Updated: Sep 8, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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Published on: June 3, 2016

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通过控制MafA表达,GPRC5B通过控制肥胖的成熟β细胞状态

Tianpeng Wang1, Remy Bonnavion1, Janett Piesker2

  • 1Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

JCI insight
|September 4, 2025
PubMed
概括

在肥胖期间,孤儿受体GPRC5B对维持胰腺β细胞功能至关重要. 通过cAMP/ CREB途径影响β细胞成熟度和MafA表达,其损失会损害胰岛素分泌和葡萄糖耐受性.

关键词:
贝塔细胞内分泌学与G蛋白结合的受体代谢过程肥胖问题

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