作为免疫器官相互作用模型的器官
Marius Francisco Harter1, Timothy Recaldin2, Nikolche Gjorevski3
1Institute of Human Biology (IHB), Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland; Gustave Roussy Cancer Campus, University Paris-Saclay, Paris, France.
Cell reports
|September 4, 2025
概括
本综述探讨了与器官细胞共同培养如何模拟粘膜免疫和自身免疫性疾病. 这些先进的模型为更好的疾病理解和治疗开发提供了对免疫-上皮相互作用的新见解.
科学领域:
- 免疫学
- 机器人技术
- 在玻璃模型中
背景情况:
- 免疫-上皮相互作用对粘膜免疫,自身免疫性疾病和癌症至关重要.
- 目前的体外模型往往无法完全回顾这些相互作用的复杂性.
- 有机体技术为更多生理相关研究提供了一个有前途的平台.
研究的目的:
- 审查免疫器官共同培养在粘膜免疫模型中的应用.
- 讨论炎症性器官系统在理解自身免疫性疾病中的应用.
- 探索患者产生的有机体与癌症研究的免疫成分的潜力.
主要方法:
- 详细审查有关免疫器官共同培养系统的现有文献.
- 分析这些系统如何模拟炎症反应和疾病发病.
- 讨论未来发展更复杂和预测模型的方向.
主要成果:
- 免疫器官共同培养可以有效地模拟粘膜炎症反应的各个阶段.
- 炎症性器官系统提供了对慢性压力和自身免疫疾病重塑的见解.
- 与免疫细胞结合的患者衍生癌细胞显示出瘤研究的潜力.
结论:
- 免疫器官共同培养是研究免疫-上皮相互作用的强大工具.
- 需要进一步开发以在这些系统中建立稳态动力学和免疫记忆.
- 这些先进的模型将加深我们对健康和疾病的免疫生物学的理解.
相关概念视频
Introduction to Lymphatic and Immune System
19.7K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
19.7K
Functions of the Lymphatic and Immune System
8.3K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
8.3K
Lymphoid Cells and Tissues
3.9K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.9K
Primary Lymphoid Organs
16.9K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.9K
Secondary Lymphoid Organs
10.5K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.5K
Cells of the Adaptive Immune Response
10.2K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
10.2K


